Effect of polyherbal microemulsion on staphylococcus. In this method, adding the oil, surfactant mixture to some of the aqueous phase in a. How can i construct pseudoternary phase diagram to form. To understand the app you also have to understand ternary phase diagrams. Microemulsion ciclopirox olamine pseudoternary phase diagram. Pseudoternary phase diagrams of a drug delivery system. This is for a single phase, three component system. Uses a simulation to show how ternary phase diagrams are interpreted. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were. A series of ternary systems consisting of three components lemon oil, tween 20 or 80 and water were prepared at different ratios via gentle agitation by the phase inversion composition method involving the spontaneous formation of microemulsion. Throughout the article, two distinct gels, made of two different microemulsion droplets r. Peh school of pharmaceutical sciences, universiti sains malaysia, 11800 minden, penang, malaysia. Inhouse ad hoc software was created according to the proposed concept. Using these data, micellar structure maps were prepared for.
Which software is most suitable in preparing ternary phase diagrams in microemulsions. The phase diagram explorer allows you to visualise what happens when you or perhaps your customer travel a dilution path through phase diagram space. It is used in physical chemistry, petrology, mineralogy, metallurgy, and other. Microemulsion how to construct ternary phase diagram anyone provide step by. Once the proportion is determined, a similar microemulsion can be produced. Microemulsion how to construct ternary phase diagram anyone provide step by step. Phase diagrams for micellar systems are discussed in this chapter kahlweitstrey, 1985. Any cosurfactant used are usually grouped together with the surfactant at a fixed ratio and treated as a pseudocomponent.
It is the point where all three phases in a ternary diagram are partially soluble in each other. Ternary phase diagram a pseudoternary tutorial chemix school v7. Three components are the basic requirement to form a microemulsion. Smith department of ceramic engineering university of missourirolla abstract understanding and interpreting phase equilibrium diagrams is an essential skill for materials engineers. Ternary phase diagram is a very important tool to study the phase behavior of the microemulsion system. There is a solution which involves viewing the figure from below, but ill leave that for another question. The trend of growing interest in alternative source of energy focuses on renewable products worldwide. Tutorial modules for the study of phase equilibrium diagrams william g. The results showed that the wo microemulsion were located mostly at the surfactant mixtures apex and protruding towards the wateroil axis.
The model drug vitamin e was loaded in the oil phase. Phase behaviour of microemulsion the phase behaviour of simple microemulsion system composing oil, water and surfactant can be studied with the aid of ternary phase diagram. Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitatewaterbrij 97. Short oil hydrocarbon chains result in deep organic phase insertions into the interface membrane. Isopleth through hypothetical ternary phase diagram at a constant. It is the boundary line around that singlephase region. Ternary phase diagram software free download ternary. This software will generate the experimental points for diagram construction. Ternary phase diagrams were designed to determine the microemulsion. Minitab15 software was used for experimental design and the evaluation of the effect of variables on responses.
Turbidity of the samples would indicate formation of a coarse emulsion, whereas a clear isotropic solution would indicate the formation of a microemulsion. Microemulsion how to construct ternary phase diagram anyone provide step by step tutorial. Pseudoternary phase diagram construction to investigate concentration range of components for the existing boundary of mes, pseudoternary phase diagrams were constructed using the water titration method. Formulation design of microemulsion collector based on. It graphically depicts the ratios of the three variables as positions in an equilateral triangle. The pseudoternary phase diagrams for the microemulsion systems. To investigate concentration range of components for the existing boundary of mes, pseudoternary phase diagrams were constructed using the water titration method. Which software is most suitable in preparing ternary phase.
The algorithm includes a method that resolves the incompatibilities between hld and oilwater ratios. Using algebraic geometry to describe boundaries of microemulsion. Characterization of microemulsion structures in the pseudoternary. The use of pseudoternary phase diagrams to locate the microemulsion region will be described and the compositions of the template will be suggested. Chemical method, especially microemulsion flooding, plays an important role in enhanced oil recovery technique due to its.
Experimental design is an excellent tool to analyze and optimize the. The pseudo ternary phase diagrams were developed by origin software version 2018b. Preparation and evaluation of tretinoin microemulsion. A ternary phase diagram plotting software for microemulsion fuels. A ternary phase diagram is used to determine the composition of the microemulsion and the proportion of the oil phase, surfactant, and cosurfactant. Pseudoternary phase diagram of microemulsion composed. This diagram contains two binary eutectics on the two visible faces of the diagram, and a third binary eutectic between elements b and c hidden on the back of the plot. Another important variable that influences the shape of the ternary phase diagram is the length of the surfactant tail l. This research was aimed to characterize microemulsion systems of isopropyl palmitate ipp, water, and 2. Tutorial modules for the study of phase equilibrium diagrams. Can anyone recommend me some phase diagram software. Phase diagrams of wo microemulsion stabilised by non. My free book expands on the content in practical surfactants but is. The potential drug vitamin e was loaded in the oil phase.
Ternary phase diagram can be represented in a triangular format, in which each coordinate represents one component. Ternary phase diagram a pseudoternary tutorial youtube. Doptimal design and development of microemulsion based transungual drug delivery formulation of ciclopirox olamine for treatment of onychomycosis, p. If, like me, you find these difficult, you can get a quick tutorial via the phase diagram. Wxternary is a set of python scripts that can be used to plot data on a ternary diagram. Doptimal design and development of microemulsion based.
Evaluation and optimization of waterinoil microemulsion using. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Design and characterization of microemulsion systems for. Microemulsions are usually characterised by ternary phase diagrams, which three edges are the components of a microemulsion, namely, oil, water and surfactant. To deliver 2,3,5,6tetramethylpyrazine tmp in a relatively large dose through a transdermal route and facilitate the practical application of microemulison in transdermal drug delivery. Formulation and development of microemulsion and smedds akshay r.
Ternary phase diagram can be represented in a triangular format, in which each coordinate represents one component of microemulsion with 0100% concentration in the increment of 10%. Gibbs phase diagrams can be used to show the influence of changes in the volume. This page helps you map microemulsion ternary phase diagrams that have been estimated from basic surfactant properties and formulation conditions. As quaternary phase diagram four component system is time consuming and difficult to interpret, pseudo ternary phase diagram is often constructed to find the different zones including microemulsion zone, in which each corner of the diagram represents 100% of the particular component.
I have some problems representing microemulsion phase diagrams. A hypothetical ternary phase space diagram made up of metals a, b, and c is shown in fig. Microemulsion, ciclopirox olamine, pseudoternary phase diagram. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Characterization of microemulsion structures in the. Figure 5 shows the pseudoternary phase diagram with the area inside the frame assigned on the phase diagram showing the microemulsion region. Preparation of nano and microemulsions using phase. The relative amounts of these three components can be represented in a ternary phase diagram. Ternary diagrams have been constructed for 3 specific microemulsion systems showing the effects of salinity and cosurfactant on phase behavior, viscosity, resistivity, optical birefringence, and interfacial tension. Phase diagram of the microemulsion the microemulsion is treated as a pseudoternary system with oil, surfactant, and aqueous components. Ternary phase diagram that shows the 3phase region. Preparation and evaluation of tretinoin microemulsion based on pseudo ternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. Mpde practical surfactants science prof steven abbott.
The clear formulation represents the microemulsion region and hence the % oil mix, % s mix and % water sufficient to produce a clear formulation at the corresponding stages, were taken to develop a pseudo ternary phase diagram of a particular s mix ratio. Microemulsion domains are usually characterized by constructing ternaryphase diagrams. The below shows a hypothetical ternary phase diagram of a microemulsion. Can anyone help me to construct a ternary phase diagram for. This algorithm will be described in detail in upcoming articles. Construction of pseudoternary phase diagram and its evaluation. Microemulsion phase relationships in the system sodium dodecyl. A fundamental reason for the uses of these systems is that a microemulsion phase sometimes has an ultralow interfacial. The way in which i draw the surface plot in ternpcolor makes it hard to use negative values. Ternary phase diagrams institute for advanced study. The effects of different surfactants pure and mixed on the mixing diagrams. Enlargement of nanoemulsion region in pseudoternary. Sigma plot software was applied for providing tertiary phase diagrams. Ternary phase diagram basics interactive simulation.
Tretinoin, phase diagram, microemulsion, differential scanning calorimetry. Ternary phase diagram basics interactive simulation youtube. As shown, the area of the microemulsion in the pseudo ternary phase diagram is significantly affected by the chain length of the cosurfactant. The singlephase boundary line is found on any section that. Construction of pseudoternary phase diagram is an important tool for screening of selfdispersible formulation components and to assess the effect of different. Its phase diagram can be used as a guide for the selection of different microemulsion compositions for hydrothermal synthesis. However, the situation of petroleum industries in many countries needs much concern in improving the oil recovery technique. Comparison of ow and ilw microemulsion systems as potential. Take a wo microemulsion of, say, barium chloride and mix it with a wo microemulsion of, say, sodium sulfate, the two react to create nanoparticles of insoluble baso4. Formulation and characterization of microemulsion system.